An Ensemble Method of Discovering Sample Classes Using Gene Expression Profiling

نویسندگان

  • Dechang Chen
  • Zhe Zhang
  • Zhenqiu Liu
  • Xiuzhen Cheng
چکیده

1 Department of Preventive Medicine and Biometrics Uniformed Services University of the Health Sciences 4301 Jones Bridge Road, Bethesda, MD 20814, USA [email protected] 2 Department of Biomedical Engineering University of North Carolina Chapel Hill, North Carolina 27599, USA [email protected] 3 Bioinformatics Cell, TATRC 110 North Market Street, Frederick, MD 21703, USA [email protected] 4 Department of Computer Science The George Washington University 801 22nd St. NW, Washington, DC 20052, USA [email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Semiquantitative RT-PCR analysis to assess the expression levels of iNOS in chicken macrophages

Abstract: iNOS is inducible by a variety of factors related to inflammation and referred to as inducible NOS(iNOS). It is regulated at the level of gene expression; once expressed, it produces NO at a high rate. iNOS gene-expression profiling is an important tool in understanding molecular markers of the responses of cells and tissues to external factors. In this article a semiquantitative reve...

متن کامل

Systematic enrichment analysis of microRNA expression profiling studies in endometriosis

Objective(s): The purpose of this study was to conduct a meta-analysis on human microRNAs (miRNAs) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. Materials andMethods: PubMed, Embase, Web of Science, Ovid Medline were used to search for endometriosis miRNA expression profiling studies of endometriosis. The miRN...

متن کامل

The algorithm of Fuzzy C-Means clustering based on non-negative matrix factorization

Clustering analysis is an effective method to discover and identify tumor classes. So, this paper proposes a Fuzzy C-Means clustering (FCM) algorithm based on Non-negative matrix factorization (NMF). Firstly, gene expression profiling (GEP) is simply processed through mean and variance of gene expression, which can then be mapped into a low dimensional space by NMF method. Finally, for discover...

متن کامل

Expression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow

Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute m...

متن کامل

Hybrid Ensemble Gene Selection Algorithm for Identifying Biomarkers from Breast Cancer Gene Expression Profiles

Breast cancer is one of the major health hazard in the world. DNA gene expression profiles plays an important role in identifying the biomarkers for cancer which not only help in accurate diagnosis of the disease, also in discovering drugs, minimizing the toxicity thus help in the effective management of the disease. In this paper we propose an algorithm for determining the biomarkers. Our hybr...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005